Linda C. Hsieh-Wilson

Milton and Rosalind Chang Professor of Chemistry; Merkin Institute Professor

B.S., Yale University, 1990; Ph.D., University of California, 1996. Assistant Professor, Caltech, 2000-06; Associate Professor, 2006-10; Professor, 2010-17. Investigator, 2005-14, Arthur and Marian Hanisch Memorial Professor of Chemistry, 2017-present.

Email: [email protected]

Phone: 626-395-6101

Office: 349A Crellin

Mail Code: MC 164-30

Research Summary

Synthetic and combinatorial chemistry; neurobiology; protein structure and function

Profile

Assistant: Annette Luymes

Research in the Hsieh-Wilson group combines organic chemistry and neurobiology to understand the molecular basis of fundamental brain processes. We apply the tools of organic synthesis, biochemistry, molecular and cellular biology, biophysics and neurobiology to manipulate and understand small molecules, proteins and molecular interactions critical for neuronal communication, development, learning and memory.

For a complete publications list, see feeds.library.caltech.edu

2022-23

Ch 41 abc. Organic Chemistry. 9 units (4-0-5); first, second, third terms, 2022-23. Prerequisites: Ch 1 ab or instructor's permission. The synthesis, structure, and reaction mechanisms of organic compounds.
Instructors: Nelson (a), Hsieh-Wilson (b), Reisman (c)

Ch 7. Advanced Experimental Methods in Bioorganic Chemistry. 9 units (1-6-2); third term, 2022-23. Prerequisites: Ch 41 abc, Ch/Bi 110 ab, and Ch 4 ab. Prerequisites may be waived with instructor's permission. Preference will be given to students who have taken Ch 5 a or Bi 10. This advanced laboratory course will provide experience in powerful contemporary methods used in chemical biology, including polypeptide synthesis and the selective labeling and imaging of glycoproteins in cells. Experiments will address amino acid protecting group strategies, biopolymer assembly and isolation, and product characterization. A strong emphasis will be placed on understanding the chemical basis underlying the successful utilization of these procedures. In addition, experiments to demonstrate the application of commercially available enzymes for useful synthetic organic transformations will be illustrated. Students need only attend two lab sections per week.
Instructor: Hsieh-Wilson

2019-20

Ch 41 abc. Organic Chemistry. 9 units (4-0-5); first, second, third terms, 2019-20. Prerequisites: Ch 1 ab or instructor's permission. The synthesis, structure, and mechanisms of reactions of organic compounds.
Instructors: Grubbs (a), Hsieh-Wilson (b), Reisman (c)

Ch 7. Advanced Experimental Methods in Bioorganic Chemistry. 9 units (1-6-2); third term, 2019-20. Prerequisites: Ch 41 abc, and Bi/Ch 110, Ch 4 ab. Enrollment by instructor's permission. Preference will be given to students who have taken Ch 5 a or Bi 10. This advanced laboratory course will provide experience in powerful contemporary methods used in chemical biology, including polypeptide synthesis and the selective labeling and imaging of glycoproteins in cells. Experiments will address amino acid protecting group strategies, biopolymer assembly and isolation, and product characterization. A strong emphasis will be placed on understanding the chemical basis underlying the successful utilization of these procedures. In addition, experiments to demonstrate the application of commercially available enzymes for useful synthetic organic transformations will be illustrated.
Instructor: Hsieh-Wilson

Publications

2022-23

2019-20