Informal Seminar - Sung-Yon Kim | Thursday, May 4, 2023 - 4 pm
Date: Thursday, May 4, 2023
Location: Chen 100
Reception: 3:30 pm
Seminar: 4 pm
Speaker: Sung-Yon Kim, Associate Professor
Seoul National University
Faculty Host: Yuki Oka
Title: Warm and full: neural circuits for behavioral regulation of homeostasis
Abstract: Many of our behaviors are intrinsically motivated by a need to maintain homeostasis, including that of body temperature, energy, and fluid levels. Despite their importance, numerous seemingly simple questions remain unresolved in this field. My presentation will focus on our ongoing efforts to address two of these issues in mouse models.
The first part tries to answer: How do we stop eating when we are "mechanically" full? Mechanosensory feedback from the digestive tract to the brain is critical for limiting excessive food and water intake, but the underlying gut-brain communication pathways and mechanisms remain poorly understood. We found that Pdyn+ neurons in the parabrachial nucleus monitor the intake of both fluids and solids, using mechanosensory signals arising from the upper digestive tract (Kim et al., Nature 2020; also see Kim et al., Nat Rev Neurosci 2022). Upon receipt of the mechanosensory signals, these neurons produce aversive and sustained appetite-suppressing signals that serve as negative feedback on ingestion to prevent harmful overconsumption. Our continuing efforts to pinpoint the precise site of the origin of mechanosensory feedback signals will also be described.
The second part attempts to address: How do we turn on the heat when it is cold? Thermoregulatory behavior is among the least-studied classic motivated behaviors—until recently, no forebrain region or cell type was shown to be necessary for these responses. We recently identified the lateral hypothalamus (LH) and its Vgat+ neurons as a necessary region and cell type (Jung et al., Neuron 2022). LH Vgat+ neurons encode thermoregulatory behavior, as well as the reward value of thermal stimuli, and parabrachial inputs are required for both this encoding and thermoregulatory behavior. Notably, two-photon Ca2+ imaging revealed distinct LH Vgat+ subpopulations encoding thermal and caloric rewards. In particular, the functional heterogeneity within the LH Vgat+ population will be discussed in detail.
In sum, our findings lay the groundwork for future research into the neural bases of behavioral thermoregulation and mechanosensory feedback control of ingestion, as well as their relationships with other motivated behaviors.
THERE ARE SOME OPENINGS TO MEET WITH DR. KIM. PLEASE CONTACT TISH CHEEK FOR SCHEDULING.