Research Summary
Synthetic and combinatorial chemistry; neurobiology; protein structure and function
Profile
Assistant: Annette Luymes
Research in the Hsieh-Wilson group combines organic chemistry and neurobiology to understand the molecular basis of fundamental brain processes. We apply the tools of organic synthesis, biochemistry, molecular and cellular biology, biophysics and neurobiology to manipulate and understand small molecules, proteins and molecular interactions critical for neuronal communication, development, learning and memory.
2025-26
Ch 41 abc. Organic Chemistry.
9 units (4-0-5); first, second, third terms, 2025-26.
Prerequisites: Ch 1 ab or instructor's permission.
The synthesis, structure, and reaction mechanisms of organic compounds.
Instructors: Robb (a), Hsieh-Wilson (b), Stoltz (c)
Instructors: Robb (a), Hsieh-Wilson (b), Stoltz (c)
Ch 7. Advanced Experimental Methods in Bioorganic Chemistry.
9 units (1-6-2); third term, 2025-26.
Prerequisites: Ch 41 abc, Ch/Bi 110 ab, and Ch 4 a or instructor's permission.
This advanced laboratory course will provide experience in contemporary methods used in chemical biology, including polypeptide synthesis and selective labeling and imaging of glycoproteins in cells. Experiments will address amino acid protecting group strategies, biopolymer assembly and isolation, and product characterization. A strong emphasis will be placed on understanding the chemical basis underlying the successful utilization of these procedures. In addition, experiments to demonstrate the application of commercially available enzymes for useful synthetic organic transformations will be illustrated.
Instructor: Hsieh-Wilson
Instructor: Hsieh-Wilson
2022-23
Ch 41 abc. Organic Chemistry.
9 units (4-0-5); first, second, third terms, 2022-23.
Prerequisites: Ch 1 ab or instructor's permission.
The synthesis, structure, and reaction mechanisms of organic compounds.
Instructors: Nelson (a), Hsieh-Wilson (b), Reisman (c)
Instructors: Nelson (a), Hsieh-Wilson (b), Reisman (c)
Ch 7. Advanced Experimental Methods in Bioorganic Chemistry.
9 units (1-6-2); third term, 2022-23.
Prerequisites: Ch 41 abc, Ch/Bi 110 ab, and Ch 4 ab.
Prerequisites may be waived with instructor's permission. Preference will be given to students who have taken Ch 5 a or Bi 10. This advanced laboratory course will provide experience in powerful contemporary methods used in chemical biology, including polypeptide synthesis and the selective labeling and imaging of glycoproteins in cells. Experiments will address amino acid protecting group strategies, biopolymer assembly and isolation, and product characterization. A strong emphasis will be placed on understanding the chemical basis underlying the successful utilization of these procedures. In addition, experiments to demonstrate the application of commercially available enzymes for useful synthetic organic transformations will be illustrated. Students need only attend two lab sections per week.
Instructor: Hsieh-Wilson
Instructor: Hsieh-Wilson
2019-20
Ch 41 abc. Organic Chemistry.
9 units (4-0-5); first, second, third terms, 2019-20.
Prerequisites: Ch 1 ab or instructor's permission.
The synthesis, structure, and mechanisms of reactions of organic compounds.
Instructors: Grubbs (a), Hsieh-Wilson (b), Reisman (c)
Instructors: Grubbs (a), Hsieh-Wilson (b), Reisman (c)