Assistant: Aracely Sustaita
Professor Dervan's research program addresses a wide range of fundamental problems at the interface of organic chemistry and biology. Elucidating the chemical principles for the molecular recognition of DNA by small molecules and their use in biology, in particular gene modulation and DNA detection, are unifying themes.
Publications
Finn, Paul B.; Bhimsaria, Devesh et al. (2020) Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome
Kurmis, Alexis A.; Dervan, Peter B. (2019) Sequence specific suppression of androgen receptor–DNA binding in vivo by a Py-Im polyamide
Dervan, Peter B. (2019) A Personal Perspective on Chemical Biology: Before the Beginning
Diaz-Perez, Silvia; Kane, Nathanael et al. (2018) Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide
Dervan, Peter B.; Kurmis, Alexis A. et al. (2018) Molecular Recognition of DNA by Py–Im Polyamides: From Discovery to Oncology In: DNA-targeting Molecules as Therapeutic Agents