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Brian M. Stoltz

Research Summary
Organic Synthetic Chemistry: the development and implementation of new strategies for the preparation of structurally complex molecules
Profile

Assistant: Tomomi Kano

Research in the Stoltz group has been initiated in the general area of chemical synthesis with a focus on the development of new strategies for the preparation of complex molecules possessing interesting structural, biological, and physical properties.

In concert with the design and development of unique and efficient synthetic strategies, we will develop new techniques and methods which will be useful in far reaching and unanticipated applications, as well as for the synthesis of the initial inspirational target. Thus, the general research paradigm within the Stoltz laboratory will be to utilize architecturally complex target molecules as the driving force behind the development of new reactions, which extend the limits of the science.

Ultimately, we will have access to important biologically active compounds prepared through novel and efficient routes, as well as new techniques for the preparation of other structurally unique targets.

Publications

For a complete publications list, see feeds.library.caltech.edu
2025-26
Ch 242 ab. Chemical Synthesis. 9 units (4-0-5); first term, 2025-26. Prerequisites: Ch 41 abc. An integrated approach to synthetic problem solving featuring an extensive review of modern synthetic reactions with concurrent development of strategies for synthesis design. Part a will focus on the application of modern methods of stereocontrol in the construction of stereochemically complex acyclic systems. Part b will focus on strategies and reactions for the synthesis of cyclic systems. Part b not offered 2025-26.
Instructor: Stoltz (a)
Ch 41 abc. Organic Chemistry. 9 units (4-0-5); first, second, third terms, 2025-26. Prerequisites: Ch 1 ab or instructor's permission. The synthesis, structure, and reaction mechanisms of organic compounds.
Instructors: Robb (a), Hsieh-Wilson (b), Stoltz (c)
2022-23
Ch 149. Tutorial in Organic Chemistry. 6 units (2-0-4); first term, 2022-23. Prerequisites: Ch 41 abc and instructor's permission. Discussion of key principles in organic chemistry, with an emphasis on reaction mechanisms and problem-solving. This course is intended primarily for first-year graduate students with a strong foundation in organic chemistry. Meets during the first three weeks of the term. Graded pass/fail.
Instructors: Fu, Stoltz
Ch 242 ab. Chemical Synthesis. 9 units (4-0-5); first, second terms, 2022-23. Prerequisites: Ch 41 abc. An integrated approach to synthetic problem solving featuring an extensive review of modern synthetic reactions with concurrent development of strategies for synthesis design. Part a will focus on the application of modern methods of stereocontrol in the construction of stereochemically complex acyclic systems. Part b will focus on strategies and reactions for the synthesis of cyclic systems.
Instructors: Stoltz (a), Reisman (b)
2019-20
Ch 149. Tutorial in Organic Chemistry. 6 units (2-0-4); first term, 2019-20. Prerequisites: Ch 41 abc and instructor's permission. Discussion of key principles in organic chemistry, with an emphasis on reaction mechanisms and problem-solving. This course is intended primarily for first-year graduate students with a strong foundation in organic chemistry. Meets during the first three weeks of the term. Graded pass/fail.
Instructors: Fu, Stoltz, Ondrus