William M. (Bil) Clemons, Jr.
Assistant: Ann Mao
The Clemons group is primarily interested in understanding the molecular details of life and as a tool we focus on "structural biology". We can't do everything...yet, so we currently work on problems related to protein transport across membranes and post-translational modification of proteins. We primarily use X-ray crystallography but also work with biochemistry, microbiology, mass spectrometry and electron microscopy.
We are currently focused on three processes involved in protein secretion. The first two systems, Sec and Tat, are pathways for proteins to be translocated across membranes. The second is the essential eukaryotic process of protein glycosylation by which sugars are added specifically to proteins. We are also interested in the general problem of the over-expression and synthesis of membrane proteins.
Publications
- Orta, Anna K.;Riera, Nadia et al. (2023) The mechanism of the phage-encoded protein antibiotic from ΦX174Science
- Mays, Alfred;Byars-Winston, Angela et al. (2023) Juneteenth in STEMM and the barriers to equitable scienceCell
- Robertson, Gail A.;Clemons, William M., Jr. et al. (2023) Being Black in biophysicsBiophysical Journal
- Mitachi, Katsuhiko;Mingle, David et al. (2022) Concise Synthesis of Tunicamycin V and Discovery of a Cytostatic DPAGT1 InhibitorAngewandte Chemie International Edition
- Fry, Michelle Y.;Najdrova, Vladimira et al. (2022) Structurally derived universal mechanism for the catalytic cycle of the tail-anchored targeting factor Get3Nature Structural & Molecular Biology
- Fry, Michelle;Najdrova, Vladimira et al. (2021) Structural characterization of the catalytic cycle of the chaperone Get3 from a human pathogenProtein Science
- Fry, Michelle Y.;Saladi, Shyam M. et al. (2021) Sequence-based features that are determinant for tail-anchored membrane protein sorting in eukaryotesTraffic
- Fry, Michelle Y.;Saladi, Shyam M. et al. (2021) The STI1-domain is a flexible alpha‐helical fold with a hydrophobic grooveProtein Science
- Lin, Ku-Feng;Fry, Michelle Y. et al. (2021) Molecular basis of tail-anchored integral membrane protein recognition by the cochaperone Sgt2Journal of Biological Chemistry
- Mitachi, Katsuhiko;Kansal, Rita G. et al. (2020) DPAGT1 Inhibitors of Capuramycin Analogues and Their Antimigratory Activities of Solid TumorsJournal of Medicinal Chemistry
2022-23
Instructors: Clemons (a), Rees (b)
Instructor: Clemons
2019-20
Instructor: Clemons
Instructors: Clemons, Jensen, and other guest lectures
Instructors: Clemons, Hoelz, Shan and various guest lecturers