Research Summary
Catalysis, enantioselective synthesis, mechanistic studies, organic chemistry, organometallic chemistry, reaction development
Profile
Assistant: Julianne Just
The Fu group is focused on the development of transition-metal catalyzed reactions for organic synthesis, with an emphasis on enantioselective processes. In particular, the group is developing nickel-catalyzed carbon–carbon bond-forming reactions of alkyl electrophiles, including enantioconvergent couplings of racemic electrophiles and racemic nucleophiles, as well as copper-catalyzed carbon–heteroatom bond-forming reactions of alkyl electrophiles, including asymmetric processes (a collaboration with the Peters lab). Mechanistic investigations play an important role in our studies.
Publications
- Hossain, Asik;Anderson, Robert L. et al. (2024) Nickel-Catalyzed Enantioconvergent and Diastereoselective Allenylation of Alkyl Electrophiles: Simultaneous Control of Central and Axial ChiralityJournal of the American Chemical Society
- Wang, Zhuo-Yan;Freas, Dylan J. et al. (2023) Phosphine Catalysis of the Fluorination of Unactivated Tertiary Alkyl Chlorides under Mild and Convenient ConditionsJournal of the American Chemical Society
- Tong, Xiaoyu;Yang, Ze‐Peng et al. (2023) Iron‐Catalyzed Reductive Cross‐Coupling of Alkyl Electrophiles with OlefinsAngewandte Chemie International Edition
- Chen, Caiyou;Fu, Gregory C. (2023) Copper-catalysed enantioconvergent alkylation of oxygen nucleophilesNature
- Zuccarello, Giuseppe;Batiste, Suzanne M. et al. (2023) Enantioselective Synthesis of α-Aminoboronic Acid Derivatives via Copper-Catalyzed N-AlkylationJournal of the American Chemical Society
- Tong, Xiaoyu;Schneck, Felix et al. (2022) Catalytic Enantioselective α-Alkylation of Amides by Unactivated Alkyl ElectrophilesJournal of the American Chemical Society
- Cho, Hyungdo;Suematsu, Hidehiro et al. (2022) Photoinduced, Copper-Catalyzed Enantioconvergent Alkylations of Anilines by Racemic Tertiary Electrophiles: Synthesis and MechanismJournal of the American Chemical Society
- Lee, Heejun;Ahn, Jun Myun et al. (2022) Investigation of the C–N Bond-Forming Step in a Photoinduced, Copper-Catalyzed Enantioconvergent N–Alkylation: Characterization and Application of a Stabilized Organic Radical as a Mechanistic ProbeJournal of the American Chemical Society
- Chen, Caiyou;Peters, Jonas C. et al. (2021) Photoinduced copper-catalysed asymmetric amidation via ligand cooperativityNature
- Yang, Ze-Peng;Freas, Dylan J. et al. (2021) Asymmetric Synthesis of Protected Unnatural α-Amino Acids via Enantioconvergent Nickel-Catalyzed Cross-CouplingJournal of the American Chemical Society
2022-23
Ch 104. Intermediate Organic Chemistry.
9 units (4-0-5); second term, 2022-23.
Prerequisites: Ch 41 abc.
A survey of selected topics beyond introductory organic chemistry, including reaction mechanisms and catalysis.
Instructor: Fu
Instructor: Fu
Ch 149. Tutorial in Organic Chemistry.
6 units (2-0-4); first term, 2022-23.
Prerequisites: Ch 41 abc and instructor's permission.
Discussion of key principles in organic chemistry, with an emphasis on reaction mechanisms and problem-solving. This course is intended primarily for first-year graduate students with a strong foundation in organic chemistry. Meets during the first three weeks of the term. Graded pass/fail.
Instructors: Fu, Stoltz
Instructors: Fu, Stoltz
2019-20
Ch 104. Intermediate Organic Chemistry.
9 units (4-0-5); second term, 2019-20.
Prerequisites: Ch 41 abc.
A survey of selected topics beyond introductory organic chemistry, including reaction mechanisms and catalysis.
Instructor: Fu
Instructor: Fu
Ch 149. Tutorial in Organic Chemistry.
6 units (2-0-4); first term, 2019-20.
Prerequisites: Ch 41 abc and instructor's permission.
Discussion of key principles in organic chemistry, with an emphasis on reaction mechanisms and problem-solving. This course is intended primarily for first-year graduate students with a strong foundation in organic chemistry. Meets during the first three weeks of the term. Graded pass/fail.
Instructors: Fu, Stoltz, Ondrus
Instructors: Fu, Stoltz, Ondrus