Organic Chemistry Seminar

Wednesday, May 21, 2014

4:00pm to 5:00pm

Noyes 153 (J. Holmes Sturdivant Lecture Hall)

Small Molecule Probes of APOBEC3 DNA Cytosine Deaminases

Daniel A. Harki, Assistant Professor of Medicinal Chemistry, Medicinal Chemistry Department, University of Minnesota,

APOBEC3 enzymes are a family of human DNA cytosine-to-uracil deaminases that degrade foreign DNA as part of the innate immune response to pathogens. However, cytosolic APOBEC3 enzymes, namely APOBEC3G, has been implicated in promoting HIV-1 mutation, which contributes to viral genetic diversity and adaptability. The nuclear enzyme, APOBEC3B, has been recently discovered as a source of endogenous mutation in cancer. Using a combination of high-throughput screening and rational analogue synthesis, first-in-class chemical probes of APOBEC3G and APOBEC3B have been developed. This presentation will discuss our efforts to develop mechanistic chemical probes of both enzymes as well as ongoing work to identify new chemotypes with enhanced potency and specificity for cellular and animal studies.

For more information, please contact Lynne Martinez by phone at 626-395-4004 or by email at [email protected].

Event Series

Organic Chemistry Seminar Series

Event Sponsors

Division of Chemistry and Chemical Engineering More Events from this Sponsor