DRAFT

Organic Chemistry Seminar

Wednesday, May 18, 2022
2:00pm to 3:00pm
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Gates Annex B122
Biocatalysis and complex molecule synthesis
Alison Narayan, Associate Professor, Department of Chemistry, University of Michigan,

Hybrid event

Natural sources, such as plants, fungi and microbes, have historically provided compounds with potent pharmaceutical properties. While it can be challenging to build complex natural products in a lab using existing chemistry methods, Nature has perfected these biosynthetic pathways. The work described leverages the power of Nature's tools for building complex molecules to synthesize novel molecules with therapeutic potential. The reactivity and selectivity of enzymes from natural product pathways are often unparalleled in existing chemical methods. Enzymes with potential synthetic utility are used as a starting point for engineering biocatalysts with (1) broad substrate scope, (2) high catalytic efficiency, and (3) exquisite site- and stereoselectivity. These biocatalytic methods are employed to efficiently synthesize biologically active complex molecules.

For more information, please contact Annette Luymes by phone at 626-395-6016 or by email at aluymes@caltech.edu.