Organic Chemistry Special Seminar
Guosheng Liu obtained his Ph.D. degree under the supervision of Prof. Xiyan Lu at SOC in 2002. From 2003 to 2007, he conducted postdoctoral research at Lehigh University with Prof. Li Jia and University of Wisconsin-Madison with Prof. Shannon S. Stahl. Then, he started his independent academic career at SIOC, CAS since 2007. His current research interest includes the development of novel synthetic methodologies on the selective difunctionalization of alkenes and sp3 C−H functionalization, including transition metal-catalyzed fluorination as well as asymmetric radical control. Recently, he received a Friedrich Wilhelm Bessel Research Award from Alexander von Humboldt Fundation.
Due to the highly active radical intermediate, the organic transformation via radical pathway have been extensively studied. However, the selective control of radical intermediate is extremely challenging, which significantly retards the success of highly selective radical reaction, specially for the enantioselective version. Recently, Our group recently reveals that the stereoselective control of radical could be achieved by using copper catalyst, and a series of enantioselective difunctionalization of alkenes have been explored by using bisoxazoline (Box)/Cu(I) catalytic system. In these studies, a benzylic radical intermediate was involved in the catalytic cycles, which can be enantioselectively traped by (Box)/CuII intermediate to produce enantiomerically enriched products. In this talk, I'd like to introduced our recent progress in the asymmetric oxidative functionalization of C-H bonds, including benzylic and allylic C-H bonds, wherein copper catalyst plays important roles on the both site- and enantioselectivity.