BMB/Ch 178. Macromolecular Function: Kinetics, Energetics, and Mechanisms. 9 units (3-0-6); first term. Prerequisites: Bi/Ch 110 or equivalent. Discussion of the energetic principles and molecular mechanisms that underlie enzyme's catalytic proficiency and exquisite specificity. Principles of allosteric regulation, selectivity, enzyme evolution, and computational enzyme design. Practical kinetics sections discuss how to infer molecular mechanisms from rate/equilibrium measurements and their application to more complex biological systems, including steady-state and pre-steady-state kinetics, kinetic simulations, and kinetics at the single molecule resolution. Instructor: Shan.