Wednesday, June 27, 2018
4:00 pm
Noyes 153 (J. Holmes Sturdivant Lecture Hall)

Organic Chemistry Seminar

Synthesis of Unprecedented Hydrocarbons and Their Deployment in Step Economic Total Synthesis
Michael Sherburn, Professor, Research School of Chemistry, Australia National University

The two simplest acyclic branched structures comprising only conjugated C=C units, namely [3]dendralene (3-methylene-1,4-pentadiene) and [4]dendralene (3,4-dimethylene-1,5-hexadiene), were first reported in 1955 and 1962, respectively. No higher members of the series were described in the literature until the year 2000. We have played a dominant role in the push for a deeper understanding of these compounds and their synthetic potential. This greater appreciation of C=C bond rich systems has led to the successful synthesis of many unprecedented structures, including [5]radialene, the simplest cyclic branched pentaene. This presentation will focus on various aspects of the chemistry involved in the preparation of branched C=C bond rich compounds, and their deployment in the most step economic total syntheses of natural products.

Contact Annette Luymes aluymes@caltech.edu at 626-395-6016
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